Helicobacter Pylori Infection and Upper Gastro-Intestinal Bleeding ab 45.99 € als Taschenbuch: in Northern Iranian Children. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Helicobacter Pylori Infection and Upper Gastro-Intestinal Bleeding ab 45.99 EURO in Northern Iranian Children
Prevalence of Helicobacter pylori (H. pylori) is very high and well documented in gastroenterological disorders like gastritis, gastric carcinoma, peptic ulcer disease, non ulcer dyspepsia and gastroesophageal reflux disease. More than 50% of the world's population harbor Helicobacter pylori in their upper gastrointestinal tract. It causes a chronic low-level inflammation of the stomach lining and is strongly linked to the development of duodenal and gastric ulcers and stomach cancer. This book will provide the readers a better understanding about the H. pylori related gastroenterological disorders and their proper management with clinical comparative research oriented herbal medicines.
Recently the diabetes mellitus has been known as one of the main cause of upper gastrointestinal symptoms. Since high prevalence of Helicobacter Pylori in diabetic patients has been reported. The aim of this study was to evaluate the relationship between the level of gastric juice Nitric Oxide, Oxidative Stress and Hyperglycemic Control in diabetic H. Pylori infected patients. In patients with metabolically uncontrolled diabetes mellitus the prevalence of H. Pylori infection is high and the bacteria colonization occurs at the antrum of stomach. After eradication therapy of H. Pylori the control of the glyceamia will be useful. Increased levels of HbA1C in the case group in comparison with those in the uninfected subjects confirm the finding. On the other hand the treatment of the H. Pylori infection improves the level of NO° in the gastric juice and reduces cellular damage resulting from acute oxidative stress produced by reaction between superoxide radicals of H. Pylori and NO° of the gastric juice.
More than 50% of the world's population harbor Helicobacter pylori in their upper gastrointestinal tract. H. pylori persistently infects gastric mucosa and is associated with several diseases including peptic ulcer disease and gastric carcinoma. One of the most thoroughly studied virulence factors produced by H. pylori is the Vacuolating Cytotoxin A (VacA).The protein binds to the host cells and is internalized. Inside the host cells, it causes "vacuole"-like membrane vesicles in the cytoplasm of gastric epithelial cells. Besides vacuolation, VacA exerts various other effects on target cells. VacA also forms membrane-embedded pores at the inner-mitochondrial membrane, resulting in mitochondrial dysfunction by cytochrome c release and apoptosis induction. VacA suppresses nuclear translocation of nuclear factor of activated T-cells (NFAT) resulting in down regulation of interleukin-2 (IL2) gene transcription to efficiently block proliferation of T-cells. This book underlines the results showing involvement of VacA in the modulation of intracellular calcium signalling and therefore will provide new insights that are required to understand how VacA inhibits T-cell proliferation.
One in every eight cancers in the world develops in the oesophagus or stomach. While the incidence of gastric adenocarcinoma and oesophageal squamous cell carcinoma have declined in recent decades, oesophageal adenocarcinoma has increased more than any other cancer. Infection with Helicobacter pylori, dietary salt and smoking are the main risk factors for gastric and oesophageal cancer. Gastro-oesophageal reflux disease (GORD), Barrett s oesophagus and obesity are risk factors for oesophageal adenocarcinoma. Adenocarcinomas of the oesophago-gastric junction and cardia include two distinct types, one resembling gastric cancer caused by H.pylori infection, the other, associated with GORD, resembling Barrett s adenocarcinoma. Gender is also a major intrinsic factor, with upper gastrointestinal cancer much commoner in men. The current work examines this male predominance at the population level and with reference to Lauren histological type, showing that only intestinal-type but not diffuse type upper GI cancers occur more frequently in men.
Helicobacter pylori (H. Pylori) infection is associated with many upper gastrointestinal diseases such as chronic gastritis, peptic ulcer and gastric carcinoma. Furazolidone is an effective drug in the treatment of GIT infections. Furazolidone has short half-life and need to administrate on frequent basis. This book discuss design, development and optimization of sustained release intra-gastric in situ floating gel system of Furazolidone for the potential use in treatment of gastric and duodenal ulcers associated with H. Pylori. Furazolidone gelling solution (FISG) was prepared using natural biodegradable polymers Xanthan gum, Gellan gum and Locust bean gum. The polymeric system was optimized by calcium carbonate and sodium citrate. Effect of beta CD was also evaluated. The optimized FISG was evaluated for gelling properties, floating lag time, rheological properties, drug content, FT-IR and DSC. All optimized solutions had shown pseudoplastic flow with good gel strength and gelled immediately at acidic pH 1.2. The dissolution study indicated sustained release of drug. The book will be useful for the researchers working in the areas of formulation development of pharmaceuticals.
The discovery of Helicobacter pylori as the cause of peptic ulcer has revolutionized anti-ulcer treatment. The current treatment includes a combination of antibiotics with proton pump inhibitors or H2 receptor antagonist1,2. Clarithromycin and omeprazole combination has become popular and best choice for treating peptic ulcer associated with H. pylori infection3. Gastro retentive dosage forms have the potential for increased residence in stomach along with site-specific drug delivery. Hydrodynamic drug delivery systems (HBS) are one such systems that has increased gastric residence providing an increased local action at the ulcer site4. Clarithromycin, effective in H.pylori infection treatment was chosen as model drug. Extended release and retention in upper gastro intestinal tract would be most advantageous, optimizing the combination therapy of peptic ulcer complicated with H.pylori. Omeprazole was formulated as fast dissolving enteric-coated pellets by using extrusion spheronisation technique. Enteric coating material used was Eudragit 30D-L-55.
There are controversies regarding relationship between Helicobacter pylori (H. pylori) and upper gastro-intestinal bleeding (UGIB )in children. The goal of this study was to assess the relationship between H. pylori infection and UGIB in Northern Iranian children. One hundred children who had UGIB indicated for upper gastrointestinal endoscopy and 100 children without UGIB who were candidate for upper endoscopy because of chronic abdominal pain considered as their controls. After stabling vital sign, nasogastric tube inserted and washing was done then within 24 hours of admission, endoscopy conducted for all children in the case group (under general anesthesia). Upper endoscopy was done for all participants by a children gastroenterologist. A single pathologist reviewed all specimens. Mean age of cases was 6.2±3.2 years and mean age of controls was 7.1±2.9 years respectively. There was no relationship between H. pylori and UGIB. Erosion in fondus was significantly higher in cases (0.001) and erythema in antrum was significantly higher in controls (p0.001).