Erscheinungsdatum: 21.11.2013, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Multiparticulate System For Peptic Ulcer, Titelzusatz: Novel Drug Delivery System For Helicobacter Pylori Induced Peptic Ulcer, Autor: Pandit, Vinay // Suresh, Sarasija, Verlag: LAP Lambert Academic Publishing, Sprache: Englisch, Rubrik: Pharmazie // Pharmakologie, Toxikologie, Seiten: 132, Informationen: Paperback, Gewicht: 213 gr, Verkäufer: averdo
Erscheinungsdatum: 23.05.2014, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Helicobacter Pylori Cag A antibodies and their clinical implications, Titelzusatz: Correlation of Helicobacter pylori CagA antibodies with treatment resistance, bleeding ulcer and gastric cancer, Autor: Ilie, Madalina // Dascalu, Luminita // Macovei, Radu Alexandru, Verlag: LAP Lambert Academic Publishing, Sprache: Englisch, Rubrik: Medizin // Allgemeines, Lexika, Seiten: 112, Informationen: Paperback, Gewicht: 194 gr, Verkäufer: averdo
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Helicobacter species pylori represent one of the medically prominent and most common infections in the world. Contamination with this microbe has set as a causal factor in the development of gastritis, peptic ulcer, and gastric neoplasia. Consequently, prompt diagnosis is essential. Therefore, regarding all facts about the strong correlation between H. pylori and different upper gastrointestinal lesions, it is very crucial to specify the presence of this bacteria in gastric biopsy reports as it has an important role in the therapeutic implications too. Since, over years pathologists have sought different reliable methods for detecting H. pylori in biopsy specimens, including special stains, immunohistochemistry (IHC), polymerase chain reaction (PCR), and lately, in situ hybridization.
Helicobacter pylori cagPAI genes play an important role in pathogenesis, however little is known about their functions in isolates from Turkish patients. We aimed to evaluate the intactness and the effect of the cagPAI genes (cagT, cagM, cagE, cagA) and cagA EPIYA motifs on the AGS morphological changes and IL-8 induction. Isolates from gastritis, duodenal and gastric ulcer patients with intact and partially deleted cagPAI genes induced higher IL-8 secretion than those with complete deletions.Infection of AGS cells with isolates that possess intact cagPAI and EPIYA-ABC resulted in the formation of the hummingbird phenotype. The cagA positive isolates induced higher IL-8 secretion than cagA negative isolates. Isolates from DU patients with more than one EPIYA-C motif induced higher concentrations of IL-8 than those with EPIYA-ABC. In conclusion, the intactness of the cagPAI in our isolates from different patients was not conserved. An intact cagPAI was found to play an important role in the pathogenesis of DU but not GU or gastritis. The cagA gene, but not other cagPAI genes, was associated with the induction of IL-8 and the morphological changes of the AGS cells.
Introduction: Peptic ulcer disease (PUD) is the erosion in lining of stomach or duodenum. Predominantly caused by Helicobacter pylori infection in about 50% of the world's population.which can colonize in the gastric antrum of all patients producing an extensive, noninvasive inflammatory reaction in the gastric mucosa.Methods: Fortey patients newly diagnosed endoscopically with peptic ulcer disease to be allocated into group 1 treated with standard H. pylori eradication triple therapy, and group 2 patients treated with curcumin (500 mg) capsules three times daily for 14 days as an adjuvant to standard triple therapy.Results: The result showed that the use of curcumin as adjuvant therapy produced highly significant improvement in healing efficacy which was significantly distinguished in duodenal ulcer patients compared to gastric ulcer groups 2 patients (p0.05), along with a highly significant reduction in pro-inflammatory IL-1beta level in group 2 patients (p0.01). Conclusion: This study revealed that addition of curcumin as adjuvant therapy produced improvement in ulcer healing efficacy, and controlled the inflammatory and oxidative stress process induced by H. pylori infection.
Prevalence of Helicobacter pylori (H. pylori) is very high and well documented in gastroenterological disorders like gastritis, gastric carcinoma, peptic ulcer disease, non ulcer dyspepsia and gastroesophageal reflux disease. More than 50% of the world's population harbor Helicobacter pylori in their upper gastrointestinal tract. It causes a chronic low-level inflammation of the stomach lining and is strongly linked to the development of duodenal and gastric ulcers and stomach cancer. This book will provide the readers a better understanding about the H. pylori related gastroenterological disorders and their proper management with clinical comparative research oriented herbal medicines.
Gastric ulcers are erupted when there is an disproportion between the digestive juices generated by the stomach and the diverse factors that defend the mucosal lining of the stomach. Acute gastric problem reduces quickly but Chronic gastric problems lead to ulcers. Nine out of ten Peptic ulcer disease(PUD) or peptic ulcer or stomach ulcer (Gastric and duodenal ulcers) are sore on the inner lining of stomach or deodenum and caused by an infection from the bacterium H. pylori and they are liable to reappear if left untreated. An ulcer in the stomach is called as a gastric ulcer, an ulcer in the duodenum is known as a duodenal ulcer, and a peptic ulcer of the esophagus is an esophageal ulcer. Peptic ulcer disease is suspect in patients with epigastic distress and pain. Peptic ulcers are usually caused by either Helicobacter pylori (H. pylori) bacteria or non-steroidal anti-inflammatory drugs such as Aspirin, Ibuprofen or other NSAIDs.