Helicobacter Pylori Cag A antibodies and their clinical implications ab 23.9 € als Taschenbuch: Correlation of Helicobacter pylori CagA antibodies with treatment resistance bleeding ulcer and gastric cancer. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Helicobacter Pylori and Intestinal Parasite and their Risk Factors ab 35.99 € als Taschenbuch: . Aus dem Bereich: Bücher, Wissenschaft, Biologie,
Helicobacter Pylori Cag A antibodies and their clinical implications ab 23.9 EURO Correlation of Helicobacter pylori CagA antibodies with treatment resistance bleeding ulcer and gastric cancer
There are controversies regarding relationship between Helicobacter pylori (H. pylori) and upper gastro-intestinal bleeding (UGIB )in children. The goal of this study was to assess the relationship between H. pylori infection and UGIB in Northern Iranian children. One hundred children who had UGIB indicated for upper gastrointestinal endoscopy and 100 children without UGIB who were candidate for upper endoscopy because of chronic abdominal pain considered as their controls. After stabling vital sign, nasogastric tube inserted and washing was done then within 24 hours of admission, endoscopy conducted for all children in the case group (under general anesthesia). Upper endoscopy was done for all participants by a children gastroenterologist. A single pathologist reviewed all specimens. Mean age of cases was 6.2±3.2 years and mean age of controls was 7.1±2.9 years respectively. There was no relationship between H. pylori and UGIB. Erosion in fondus was significantly higher in cases (0.001) and erythema in antrum was significantly higher in controls (p0.001).
The content of the present investigation was to formulate and evaluate floating-bioadhesive tablets of amoxicillin trihydrate (ATFBT) to provide local action in the treatment of Helicobacter Pylori (H. Pylori) by prolonging the gastric residence time. The FBT were prepared by direct compression method using combination of hydroxy propyl methyl cellulose (HPMC K4M) and chitosan (CH), carbopol (CP974P) and polymethacrylic acid (PMA) as release retardants and bioadhesive polymers, and sodium bicarbonate (NaHCO3) as a gas-former. The prepared tablets were evaluated for their physical characters such as drug content, in vitro buoyancy, swelling index, in vitro drug release and stability studies. Further, the bioadhesive strength (BS) was determined using porcine gastric mucosa. DSC studies indicate the compatibility of the drug and excipients used in the formulation. The optimized formulation (F7) showed floating lag time of 32 ± 2.7 sec, total floating time more than 12 h, BS of 1.86±0.14 N, swelling index of more than 3.5 and was found to be physically stable when stored at 40oC/75% RH for 3 months.
Helicobacter is a genus of Gram-negative bacteria possessing a characteristic helix shape. They were initially considered to be members of the Campylobacter genus, but since 1989 they have been grouped in their own genus.
High Quality Content by WIKIPEDIA articles! The Proteobacteria are a major group (phylum) of bacteria. They include a wide variety of pathogens, such as Escherichia, Salmonella, Vibrio, Helicobacter, and many other notable genera. Others are free-living, and include many of the bacteria responsible for nitrogen fixation. Because of the great diversity of forms found in this group, the Proteobacteria are named after Proteus, the Greek god of the sea, capable of assuming many different shapes. All proteobacteria are Gram-negative, with an outer membrane mainly composed of lipopolysaccharides. Many move about using flagella, but some are non-motile or rely on bacterial gliding. The last include the myxobacteria, a unique group of bacteria that can aggregate to form multicellular fruiting bodies. There is also a wide variety in the types of metabolism. Most members are facultatively or obligately anaerobic, chemoautotrophs, and heterotrophic, but there are numerous exceptions. A variety of genera, which are not closely related to each other, convert energy from light through photosynthesis. These are called purple bacteria, referring to their mostly reddish pigmentation.
More than 50% of the world's population harbor Helicobacter pylori in their upper gastrointestinal tract. H. pylori persistently infects gastric mucosa and is associated with several diseases including peptic ulcer disease and gastric carcinoma. One of the most thoroughly studied virulence factors produced by H. pylori is the Vacuolating Cytotoxin A (VacA).The protein binds to the host cells and is internalized. Inside the host cells, it causes "vacuole"-like membrane vesicles in the cytoplasm of gastric epithelial cells. Besides vacuolation, VacA exerts various other effects on target cells. VacA also forms membrane-embedded pores at the inner-mitochondrial membrane, resulting in mitochondrial dysfunction by cytochrome c release and apoptosis induction. VacA suppresses nuclear translocation of nuclear factor of activated T-cells (NFAT) resulting in down regulation of interleukin-2 (IL2) gene transcription to efficiently block proliferation of T-cells. This book underlines the results showing involvement of VacA in the modulation of intracellular calcium signalling and therefore will provide new insights that are required to understand how VacA inhibits T-cell proliferation.
The study concluded that IPI infection was high prevalent compared with H. pylori infection in the study area, prevalence rates of with H. pylori and IPI were (14.6%), (26.7%) respectively in subjects under study by using stool Ag test, and direct wet mount and FECT respectively. Females were found to be more affected than males by both pathogens. The prevalence of IPI and H. pylori was higher in the age group 10-15 years old than other age groups this is due to large number of study sample under this group. The study concluded that of IPI and H. pylori is possibly a burden in asymptomatic study area, due to social, economic, and environmental risk factors.