Helicobacter Pylori Cag A antibodies and their clinical implications ab 23.99 € als Taschenbuch: Correlation of Helicobacter pylori CagA antibodies with treatment resistance bleeding ulcer and gas. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Helicobacter Pylori and Intestinal Parasite and their Risk Factors ab 35.99 € als Taschenbuch: . Aus dem Bereich: Bücher, Wissenschaft, Biologie,
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.
Bacterial infections cause substantial morbidity and mortality in cancer patients. These infections always remained enigmatic due to initial reluctance of cancer researchers in understanding their etiologic potential. Etiological association of bacteria with cancer gained credibility after discovery of carcinogenic potential of Helicobacter pylori. Moreover, other suspected associations including Salmonella typhi and gallbladder cancer, Streptococcus bovis and colon cancer and Chlamydia pneumoniae with ocular adnexal lymphoma etc. are looking for a legitimate appraisal to unravel their etiologic potential without prejudice. In contrary, bacteria also shows protective role for certain types of cancer. Certain agents derived from bacteria are successfully used for the management of cancer. The integrate association of bacteria and cancer association is evident in both positive and negative aspects. The role of bacteria in cancer etiology and treatment has been vigorously studied since last few years. Present book tries to provide current status of research undergoing in above direction, with the glimpses of future possibility for utilizing microbiological knowledge in the management of this deadly killer. This book will interest specialist dealing with cancer associated infectious complications, researchers working in the field of cancer biology, teachers and scientist in the field of microbiology, biotechnology, medicine and oncology. The unique coverage of bacteriology and cancer association in both positive and negative way can usher into to development of novel thrust area for microbiology students and experts.
Identifying Helicobacter infection as the leading cause of peptic ulcer disease and gastric cancer has dramatically altered the treatment of these disease states. Over the last several decades, scientists have come to understand that the interplay between the bacteria, the host, and the environment all contribute to the clinical outcome of infection. In Helicobacter Species: Methods and Protocols, expert researchers in the field detail many of the methods and which are now commonly used to study Helicobacter infection. These include protocols and methods that have evolved over time, and standards across the field have been established which are essential for optimal outcomes and to allow comparison of data across different laboratories. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Helicobacter Species: Methods and Protocols seeks to aid scientists in further study of this crucially important research into Helicobacter research.
The central role of RNA in many cellular processes has created a high interest in the specific tasks RNA molecules and protein: RNA complexes perform in a cell. In this publication up-to-date experimental methods and protein:RNA interaction protocols were used to identify the native RNA binding motive and to characterize the key role of the protein ribosomal binding factor A(RbfA). To gain insights into the binding mode of RbfA toits target RNA, two RbfA constructs from Thermotoga maritima and Helicobacter pylori were employed. Comparison of the RbfA proteins with the published homologous structure from Escherichia coli, led to studies concerning the structural attributes between proteins from thermophilic and mesophilic systems. The different chapters detail the biophysical and biochemical methods used to investigatethe protein and protein: RNA structures and their function and the advances in understanding the biological processes in which the RbfA protein is involved in.
The ability of bacterial colonies to induce hemolysis when grown on blood agar is used to classify certain microorganisms. They are three types of hemolysis alpha, beta and gamma. Alpha hemolysis is partial hemolysis andcalled green hemolysis because of the color change in the agar.Beta hemolysis is complete hemolysis, is a complete lysis of red cells in the media and appearlightened and transparent.Gamma hemolysis is non-hemolytic. A substance that causes hemolysis is a hemolysin Hemolysins are certain proteins and lipids that cause lysis of red blood cells by damaging their cell membrane.Although hemolysins are able to lyse red blood cells in vitro, the ability of hemolysins to target other cells, including white blood cells, often accounts for the effects of hemolysins during infection. Pathogenic Hemolytic Bacteria may be gram positive bacteria such as (staphylococcus, streptococcus, bacillus and listeria ) Gram negative bacteria such as (Neisseria, Pseudomonas,Haemophilus,Helicobacter, Escherichi, Klebsiella, Salmonella, Shigella and Proteus),Study general characterstics of each bacterium that cause human diseases.
An optimized Ethylcellulose microspheres of Clarithromycin were successfully prepared using emulsion/ solvent evaporation method and Con-A was successfully attached to the microspheres using carbodiimide method. Attachment of lectin to the Ethylcellulose microspheres significantly increased the mucoadhesiveness and also controls the release of Clarithromycin in simulated GI fluids. Conjugation aggregation assay suggesting that the lectin can be able to target in the treatment of Helicobacter pylori infection in peptic ulcer disease. Gamma scintigraphy study suggesting that Con-A lectin conjugated Ethylcellulose microspheres have gained considerable attention due to their ability to adhere to the mucus layer, as well as to release the drug in a controlled manner. It is concluded that designed targeted delivery system could possibly increases the bioavailability of Clarithromycin and treated the gastric ulcer in an effective manner.
Gall stones are a major cause of morbidity throughout the world, it represents a prevalent and costly health problem .The old axiom, that a typical gall stone sufferer is a fat, fertile, female of fifty, is only partially true, as the disease has been found in women soon after their first delivery and also in underweight and thin people . Other factors like bacterial population include Helicobacter pylori could have a possible role in gall stone formation. This book analyzed the risk factors for gall stone in Basra including Helicobacter pylori infection .