Erscheinungsdatum: 08/2012, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Lectin Conjugated Gastro-Retentive Delivery System, Titelzusatz: Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori, Autor: Jain, Sunil K. // Jangdey, Manmohan Singh, Verlag: LAP Lambert Academic Publishing, Sprache: Englisch, Rubrik: Pharmazie // Pharmakologie, Toxikologie, Seiten: 80, Informationen: Paperback, Gewicht: 136 gr, Verkäufer: averdo
Erscheinungsdatum: 22.03.2019, Einband: Kartoniert, Titelzusatz: Ein Leitfaden für die klinische Praxis, Pocket-Leitlinien / Publikationen von Fachgesellschaften, Auflage: 12/2019, Herausgeber: elkrankheiten (DGVS), Verlag: Börm Bruckmeier Verlag GmbH, Sprache: Deutsch, Schlagworte: Antiinfektivaresistenzen // Arzneimittel // Barrett-Syndrom // bildgebende Diagnostik // Blutprodukte // Darmerkrankungen // Diagnosen // DRG // Endoskopie // Endosonographie // Enteroskopie // Exklusiva // Fibrose // Funktionseinschränkung // Gastritis // Gastroenteritis // Gastroenterologie // G-DRG-System // GI-Blutung // Helicobacter pylori // Immunadsorption // Influenzaviren // Inklusiva // Kodierhilfen // Kodierleitfaden // Kodierregeln // Kodierrichtlinien // Kodierung // Komorbiditäten // Krankheiten // Krankheitsbilder // Laparoskopie // Leberersatztherapie // Leberzirrhose // Lokaltherapie // Magenballon // Nebenwirkungen // Neoplasmen // OPS-Kodes // Ösophagitis // Ösophagusulkus // Palliativbehandlung // Pankreatitis // PEG // PEJ // Pneumonie // Prothesen // Prozeduren // Seitenlokalisation // SIRS, Produktform: Kartoniert, Umfang: 208 S., Seiten: 208, Format: 1 x 14.8 x 10.5 cm, Gewicht: 129 gr, Verkäufer: averdo
Lectin Conjugated Gastro-Retentive Delivery System ab 49 € als Taschenbuch: Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Lectin Conjugated Gastro-Retentive Delivery System ab 49 EURO Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori
Helicobacter pylori (H. Pylori) infection is associated with many upper gastrointestinal diseases such as chronic gastritis, peptic ulcer and gastric carcinoma. Furazolidone is an effective drug in the treatment of GIT infections. Furazolidone has short half-life and need to administrate on frequent basis. This book discuss design, development and optimization of sustained release intra-gastric in situ floating gel system of Furazolidone for the potential use in treatment of gastric and duodenal ulcers associated with H. Pylori. Furazolidone gelling solution (FISG) was prepared using natural biodegradable polymers Xanthan gum, Gellan gum and Locust bean gum. The polymeric system was optimized by calcium carbonate and sodium citrate. Effect of beta CD was also evaluated. The optimized FISG was evaluated for gelling properties, floating lag time, rheological properties, drug content, FT-IR and DSC. All optimized solutions had shown pseudoplastic flow with good gel strength and gelled immediately at acidic pH 1.2. The dissolution study indicated sustained release of drug. The book will be useful for the researchers working in the areas of formulation development of pharmaceuticals.
During infection the human body interacts intimately with the infectious pathogen. It is this interaction that determines disease outcome. Upon infection the protein NF-kappaB acts as a central signal transmitter of the innate immune system. This protein has two main functions: the activation of genes important for inflammation as well as those that secure survival of the cell. This dual role provides a mechanistic link between infections and cancer development, as seen during infection with the carcinogenic bacterium Helicobacter pylori. Bacteria that develop intracellularly, such as Legionella pneumophila, depend on the survival of the host cell and can thus benefit from NF-kappaB activation. But how is NF-kappaB activated in these infections? And how is the activation terminated? The author introduces us to NF-kappaB signalling and then analyses NF-kappaB activation during infections with H. pylori or L. pneumophila. She establishes a new test system for high-throughput screenings and identifies new cellular factors important in NF-kappaB activation and termination. The identification of these factors broadens our understanding of innate immune signalling.
An optimized Ethylcellulose microspheres of Clarithromycin were successfully prepared using emulsion/ solvent evaporation method and Con-A was successfully attached to the microspheres using carbodiimide method. Attachment of lectin to the Ethylcellulose microspheres significantly increased the mucoadhesiveness and also controls the release of Clarithromycin in simulated GI fluids. Conjugation aggregation assay suggesting that the lectin can be able to target in the treatment of Helicobacter pylori infection in peptic ulcer disease. Gamma scintigraphy study suggesting that Con-A lectin conjugated Ethylcellulose microspheres have gained considerable attention due to their ability to adhere to the mucus layer, as well as to release the drug in a controlled manner. It is concluded that designed targeted delivery system could possibly increases the bioavailability of Clarithromycin and treated the gastric ulcer in an effective manner.
One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in the GI tract is to control the gastric residence time (GRT) via gastroretentive drug delivery system which will provide us with new and important therapeutic options. Controlling the residence time of a drug delivery system in a particular region of GI tract can utilize several approaches which include floating drug delivery system, high density system and mucoadhesive system. Helicobacter pylori bacteria are the causative agents of gastric ulcers.Certain conventional dosage forms fail to eradicate the bacteria from the stomach so a novel drug delivery system is the need of the hour for proper elimination of these bacteria locally as well as systemically. The gastro retentive systems can be the remedy and the substitute for the conventional dosage forms, which will have more rationality with excellent efficacy towards the eradication of H.pylori infections. The focus of the research work in this book is to formulate,evaluate and optimize the newer gastro retentive dosage forms of various approaches.