Erscheinungsdatum: 21.11.2013, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Multiparticulate System For Peptic Ulcer, Titelzusatz: Novel Drug Delivery System For Helicobacter Pylori Induced Peptic Ulcer, Autor: Pandit, Vinay // Suresh, Sarasija, Verlag: LAP Lambert Academic Publishing, Sprache: Englisch, Rubrik: Pharmazie // Pharmakologie, Toxikologie, Seiten: 132, Informationen: Paperback, Gewicht: 213 gr, Verkäufer: averdo
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Introduction: Peptic ulcer disease (PUD) is the erosion in lining of stomach or duodenum. Predominantly caused by Helicobacter pylori infection in about 50% of the world's population.which can colonize in the gastric antrum of all patients producing an extensive, noninvasive inflammatory reaction in the gastric mucosa.Methods: Fortey patients newly diagnosed endoscopically with peptic ulcer disease to be allocated into group 1 treated with standard H. pylori eradication triple therapy, and group 2 patients treated with curcumin (500 mg) capsules three times daily for 14 days as an adjuvant to standard triple therapy.Results: The result showed that the use of curcumin as adjuvant therapy produced highly significant improvement in healing efficacy which was significantly distinguished in duodenal ulcer patients compared to gastric ulcer groups 2 patients (p0.05), along with a highly significant reduction in pro-inflammatory IL-1beta level in group 2 patients (p0.01). Conclusion: This study revealed that addition of curcumin as adjuvant therapy produced improvement in ulcer healing efficacy, and controlled the inflammatory and oxidative stress process induced by H. pylori infection.
Peptic ulcer or Dyspepsia is one of the global`s diseases which causes mortality throughout the world, touching the lives of millions of peoples. For many years excess acid was believed to cause peptic ulcer. This misconception was suddenly illuminated due to the discovery of Helicobacter pylori bacteria which play a great role in the cause of peptic ulcer disease. To treat peptic ulcer natural products and modern synthetic drugs are in used but, still a complete cure has not been discovered and exploration of new antiulcer drugs has remain a field of active research. In this research a ground leaves of Tapinanthus dodoneifolius were macerated. The fractions obtained where subjected to phytochemicals screening, Antioxidant activity using DPPH and Antiulcer activity using an in vivo method on small animals. Causes, symptoms and treatment of peptic ulcer disease were discussed. The study has been a contribution to the assessment of possible antioxidant and antiulcer substances and should be useful to Biologist, Biochemists, Chemists, Health workers and other Medical practitioners.
Helicobacter pylori (H.pylori) represents one of the most common and medically prominent infection worldwide. Before the discovery of H. pylori, stomach disorders such as gastritis and peptic ulcers were ascribed to bad diet, too much coffee, or a stressful lifestyle. The disorders were treated accordingly with drugs such as antacids and proton pump inhibitors to reduce the acidity of the stomach and thus eliminate the symptoms.
This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori . Accordingly, it offers a valuable asset for scientists and clinicians alike.
Helicobacter species pylori represent one of the medically prominent and most common infections in the world. Contamination with this microbe has set as a causal factor in the development of gastritis, peptic ulcer, and gastric neoplasia. Consequently, prompt diagnosis is essential. Therefore, regarding all facts about the strong correlation between H. pylori and different upper gastrointestinal lesions, it is very crucial to specify the presence of this bacteria in gastric biopsy reports as it has an important role in the therapeutic implications too. Since, over years pathologists have sought different reliable methods for detecting H. pylori in biopsy specimens, including special stains, immunohistochemistry (IHC), polymerase chain reaction (PCR), and lately, in situ hybridization.