Mucoadhesive microcapsule used against Helicobacter pylori infection ab 49 € als Taschenbuch: Mucoadhesive microcapsule. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Mucoadhesive microcapsule used against Helicobacter pylori infection ab 49 EURO Mucoadhesive microcapsule
Mucoadhesive systems are those which bind to gastric epithelial cell surface or mucin and serve as a potential means of extending GRT of drug delivery system in the stomach by increasing the duration of contact of drug with the biological membrane. Mucoadhesive microspheres include microparticles and microcapsules (having a core of the drug) of 1-1000nm in diameter and consisting either entirely of a mucoadhesive polymer or having an outer coating of it,respectively.All duodenal ulcers and most gastric ulcers caused by H.Pylori acid inhibition with antibiotic treatment is highly effective in eradication of H. Pylori. Approximately 85-100% of all duodenal ulcers, 70-90% of all gastric ulcers are associated with H.Pylori infection in the stomach.The combination of antibiotics ie dual therapy or triple therapy is preferred for treatment of H.Pylori infection .It is proved that Clarithromycin and Omeprazole resided in the stomach for a longer period of time.,when they are administered in the form of Mucoadhesive nanoparticles than when administered as uspension. The plugging and sealing effect of Mucoadhesive nanoparticles could also impart superior targetability and protect the drug
One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in the GI tract is to control the gastric residence time (GRT) via gastroretentive drug delivery system which will provide us with new and important therapeutic options. Controlling the residence time of a drug delivery system in a particular region of GI tract can utilize several approaches which include floating drug delivery system, high density system and mucoadhesive system. Helicobacter pylori bacteria are the causative agents of gastric ulcers.Certain conventional dosage forms fail to eradicate the bacteria from the stomach so a novel drug delivery system is the need of the hour for proper elimination of these bacteria locally as well as systemically. The gastro retentive systems can be the remedy and the substitute for the conventional dosage forms, which will have more rationality with excellent efficacy towards the eradication of H.pylori infections. The focus of the research work in this book is to formulate,evaluate and optimize the newer gastro retentive dosage forms of various approaches.