Molecular Mechanisms of Inflammation: Induction Resolution and Escape by Helicobacter pylori ab 149.99 € als pdf eBook: . Aus dem Bereich: eBooks, Fachthemen & Wissenschaft, Medizin,
Molecular Mechanisms of Inflammation: Induction Resolution and Escape by Helicobacter pylori ab 160.49 € als gebundene Ausgabe: 1st ed. 2019. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Molecular Mechanisms of Inflammation: Induction Resolution and Escape by Helicobacter pylori ab 160.49 EURO 1st ed. 2019
Molecular Mechanisms of Inflammation: Induction Resolution and Escape by Helicobacter pylori ab 149.99 EURO
Stroke is one of the leading causes of mortality worldwide. Traditional atherosclerotic risk factors such as hypertension, smoking, and diabetes mellitus account for only about 50% of the clinical occurrence of cardiovascular diseases. Accordingly, a number of "newer" risk factors are emerging and are believed to play a significant role in the incidence of stroke and other cardiovascular diseases. They include homocysteine, lipoproteins, markers of inflammation, and infectious agents. There is evidence to suggest that atherosclerosis is an inflammatory disease. The lesions of atherosclerosis are believed to represent a series of highly specific cellular and molecular responses akin to an inflammatory reaction. Infectious microorganisms such as Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus are among several factors that may induce and promote inflammation and thereby atherosclerosis. C-reactive protein, fibrinogen, interleukin-6, and p-selectin are among several inflammatory markers, which reflect the generation of proinflammatory state that have proven to be a strong predictor of cardiovascular diseases and their outcome.
During infection the human body interacts intimately with the infectious pathogen. It is this interaction that determines disease outcome. Upon infection the protein NF-kappaB acts as a central signal transmitter of the innate immune system. This protein has two main functions: the activation of genes important for inflammation as well as those that secure survival of the cell. This dual role provides a mechanistic link between infections and cancer development, as seen during infection with the carcinogenic bacterium Helicobacter pylori. Bacteria that develop intracellularly, such as Legionella pneumophila, depend on the survival of the host cell and can thus benefit from NF-kappaB activation. But how is NF-kappaB activated in these infections? And how is the activation terminated? The author introduces us to NF-kappaB signalling and then analyses NF-kappaB activation during infections with H. pylori or L. pneumophila. She establishes a new test system for high-throughput screenings and identifies new cellular factors important in NF-kappaB activation and termination. The identification of these factors broadens our understanding of innate immune signalling.
Prevalence of Helicobacter pylori (H. pylori) is very high and well documented in gastroenterological disorders like gastritis, gastric carcinoma, peptic ulcer disease, non ulcer dyspepsia and gastroesophageal reflux disease. More than 50% of the world's population harbor Helicobacter pylori in their upper gastrointestinal tract. It causes a chronic low-level inflammation of the stomach lining and is strongly linked to the development of duodenal and gastric ulcers and stomach cancer. This book will provide the readers a better understanding about the H. pylori related gastroenterological disorders and their proper management with clinical comparative research oriented herbal medicines.
This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori . Accordingly, it offers a valuable asset for scientists and clinicians alike.
Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume's first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress - both in animal models and humans - in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field. TOC:Overview and Introduction to Cancer and Inflammation.- Helicobacter Pylori.- HTLV-1.- Herpes Viruses.- TNF.- TGF-ss.- Interleukin 1 (IL-1) Family of Cytokines.- IL-4/13.- IL-6 and Castleman's disease.- Interleukin 10 (IL-10) Family of Cytokines.- Cytokines in Multiple Myeloma: Therapeutic Implications.- Murine Cytokine Models and the Genesis of Cancer.- Experimental Models of Cytokines and Cancer Prevention.- Cytokines in the Tumor Stroma.- Cytokines and Angiogenesis in Tumors.- Chemokines and Receptor Expression in Tumor Progression.- The Biology of Cancer Cachexia: Role of TNF±.- IL-2.- IL-12.- The Type I Interferon Family.- Combination Cytokine Therapy.- Novel Strategies for Targeting Cytokine Administration.- Cytokines and Cancer Vaccines.- Anti-cytokine Therapy.- Cytokines in the Supportive Care of Cancer.