Erscheinungsdatum: 28.09.2015, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Innate immune signalling, Titelzusatz: NF-kappaB activation in infections with Helicobacter pylori or Legionella pneumophila, Autor: Bartfeld, Sina, Verlag: Südwestdeutscher Verlag für Hochschulschriften AG Co. KG, Sprache: Deutsch, Rubrik: Biologie // Allgemeines, Lexika, Seiten: 112, Informationen: Paperback, Gewicht: 183 gr, Verkäufer: averdo
Association of Helicobacter Pylori and Intestinal Parasites Infections ab 35.9 € als Taschenbuch: in Patients at Um Badah Health Center Khartoum State Sudan. Aus dem Bereich: Bücher, Wissenschaft, Biologie,
Association of Helicobacter Pylori and Intestinal Parasites Infections ab 35.9 EURO in Patients at Um Badah Health Center Khartoum State Sudan
Actualités sur les infections à Helicobacter pylori ab 54.9 EURO
Helicobacter pylori (H. Pylori) infection is associated with many upper gastrointestinal diseases such as chronic gastritis, peptic ulcer and gastric carcinoma. Furazolidone is an effective drug in the treatment of GIT infections. Furazolidone has short half-life and need to administrate on frequent basis. This book discuss design, development and optimization of sustained release intra-gastric in situ floating gel system of Furazolidone for the potential use in treatment of gastric and duodenal ulcers associated with H. Pylori. Furazolidone gelling solution (FISG) was prepared using natural biodegradable polymers Xanthan gum, Gellan gum and Locust bean gum. The polymeric system was optimized by calcium carbonate and sodium citrate. Effect of beta CD was also evaluated. The optimized FISG was evaluated for gelling properties, floating lag time, rheological properties, drug content, FT-IR and DSC. All optimized solutions had shown pseudoplastic flow with good gel strength and gelled immediately at acidic pH 1.2. The dissolution study indicated sustained release of drug. The book will be useful for the researchers working in the areas of formulation development of pharmaceuticals.
During infection the human body interacts intimately with the infectious pathogen. It is this interaction that determines disease outcome. Upon infection the protein NF-kappaB acts as a central signal transmitter of the innate immune system. This protein has two main functions: the activation of genes important for inflammation as well as those that secure survival of the cell. This dual role provides a mechanistic link between infections and cancer development, as seen during infection with the carcinogenic bacterium Helicobacter pylori. Bacteria that develop intracellularly, such as Legionella pneumophila, depend on the survival of the host cell and can thus benefit from NF-kappaB activation. But how is NF-kappaB activated in these infections? And how is the activation terminated? The author introduces us to NF-kappaB signalling and then analyses NF-kappaB activation during infections with H. pylori or L. pneumophila. She establishes a new test system for high-throughput screenings and identifies new cellular factors important in NF-kappaB activation and termination. The identification of these factors broadens our understanding of innate immune signalling.
A cross-sectional study was conducted in Um Bada Health Center , Khartoum State during January-May 2016 120 patients were enrolled in the study to assess the association between H. pylori and gastrointestinal parasites infections. Blood samples were assessed for the presence of H. pylori infection by Immune-Chromatographic Test, while direct smear prepared from stool samples were used to assess the presence of intestinal parasites and to detect the H. pylori antigen. 120 patient who are suffer from abdominal pain were examined for H. pylori and gastrointestinal parasites 48 infected with intestine parasites, 18 (15%) infected with G. lambilia, 30 (25%) infected with Entamoeba spp. and 72 (60%) were negative. 91(75.8%) positive with H. pylori while 29 (24.2%) were negative. There is strong association between H. pylori infection and gastrointestinal parasites p. value 0.00. Early detection and treatment of H. pylori and Gastrointestinal parasites, awareness of population about intestinal parasites and H.pylori through health education and using different diagnostic methods to explore the actual role of H.pylori and Gastrointestinal parasites.