Erscheinungsdatum: 28.09.2015, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Innate immune signalling, Titelzusatz: NF-kappaB activation in infections with Helicobacter pylori or Legionella pneumophila, Autor: Bartfeld, Sina, Verlag: Südwestdeutscher Verlag für Hochschulschriften AG Co. KG, Sprache: Deutsch, Rubrik: Biologie // Allgemeines, Lexika, Seiten: 112, Informationen: Paperback, Gewicht: 183 gr, Verkäufer: averdo
Helicobacter pylori VacA and Calcium Signalling in T-cells ab 59.9 € als Taschenbuch: How Helicobacter pylori evade immune response; An insight of VacA effects on intracellular calcium signalling in T-cells. Aus dem Bereich: Bücher, Wissenschaft, Biologie,
Helicobacter pylori VacA and Calcium Signalling in T-cells ab 59.9 EURO How Helicobacter pylori evade immune response; An insight of VacA effects on intracellular calcium signalling in T-cells
During infection the human body interacts intimately with the infectious pathogen. It is this interaction that determines disease outcome. Upon infection the protein NF-kappaB acts as a central signal transmitter of the innate immune system. This protein has two main functions: the activation of genes important for inflammation as well as those that secure survival of the cell. This dual role provides a mechanistic link between infections and cancer development, as seen during infection with the carcinogenic bacterium Helicobacter pylori. Bacteria that develop intracellularly, such as Legionella pneumophila, depend on the survival of the host cell and can thus benefit from NF-kappaB activation. But how is NF-kappaB activated in these infections? And how is the activation terminated? The author introduces us to NF-kappaB signalling and then analyses NF-kappaB activation during infections with H. pylori or L. pneumophila. She establishes a new test system for high-throughput screenings and identifies new cellular factors important in NF-kappaB activation and termination. The identification of these factors broadens our understanding of innate immune signalling.
Helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world's population. H. pylori is also classified as class I carcinogen by the World Health Organization (WHO). There is a wide spectrum of clinical consequences by H. pylori, ranging from gastric cancer to ulceration of the gastrointestinal tract. The pathogenicity of the infection depends on the strain virulence, host susceptibility and environmental co-factors. During the process of H. pylori infection, the antigens secreted from the bacterium elicit strong humoral immune responses which may serve as prospective infection biomarkers. The infection has both direct and indirect impact on economic and overall well-being of patients, hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits and vaccines.
The fourth meeting in the very successful series Helicobacter pylori: Basic Mechanisms to Clinical Cure was held on the island of Bermuda in late March 2000. This was only some two years after the third meeting in San Diego and it seemed hardly possible that there would be so much new information. However, as the contributions in this volume testify, there was plenty of exciting new information with important implications for both understanding this infection and for clinical management. Some of this information was of a fundamental nature, such as the role of the acid sensitive urel channel in regulating the influx of urea and the formation of ammonia transported back in the microbial periplasmic space to neutralize acid, the observation of genetic polymorphism of the IL-1~ gene as an explanation of achlorhydria and gastric cancer risk in the first-degree relatives of gastric cancer patients, and the peculiar biochemical and physio logical consequences of the genome of the microorganisms. The format of the meeting, with short fifteen-minute state-of-the-art pre sentations by world experts closely involved in Helicobacter research fol lowed by ample time for panel discussions, was again followed this year. Traditional aspects included detailed study of the microbial characteristics, the novel Helicobacters, the interaction with the human host, the peculiarities of the inflammatory immune response, the short and long-term mucosal consequences, the effects on acid secretion, the problem of gastric malignancy and the therapeutic possibilities.
This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori . Accordingly, it offers a valuable asset for scientists and clinicians alike.