Erscheinungsdatum: 08/2012, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Lectin Conjugated Gastro-Retentive Delivery System, Titelzusatz: Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori, Autor: Jain, Sunil K. // Jangdey, Manmohan Singh, Verlag: LAP Lambert Academic Publishing, Sprache: Englisch, Rubrik: Pharmazie // Pharmakologie, Toxikologie, Seiten: 80, Informationen: Paperback, Gewicht: 136 gr, Verkäufer: averdo
Helicobacter Pylori Infection and Upper Gastro-Intestinal Bleeding ab 45.99 € als Taschenbuch: in Northern Iranian Children. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Lectin Conjugated Gastro-Retentive Delivery System ab 49 € als Taschenbuch: Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Helicobacter Pylori Infection and Upper Gastro-Intestinal Bleeding ab 45.99 EURO in Northern Iranian Children
Lectin Conjugated Gastro-Retentive Delivery System ab 49 EURO Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori
This book compared the effectiveness of sequential therapy to standard triple therapy in the eradication of Helicobacter Pylori which is the main known cause of gastritis gastro-duodenal ulcer disease and gastric cancer. However, after more than 20 years of experience in H. pylori treatment, the ideal regimen to treat this infection has still to be found. Currently, apart from having a good knowledge of first-line eradication regimens, clinicians involved in the treatment of diseases caused by this pathogen must also be prepared to accept failures. Therefore, those involved in the design of a treatment strategy should not focus on the results of primary therapy alone, but also the make choices regarding a 'rescue' based on the overall eradication rate. According to several international guidelines, the first-line therapy for treating H. pylori infection consists of a proton pump inhibitor with any of two antibiotics, given for a 7-14 day period. However, even with these recommended regimens, H. pylori eradication failure is still observed in more than 20% of patients, and the failure rate of first-line therapy may be higher in clinical practice. Therefore, an alternative sequen
One in every eight cancers in the world develops in the oesophagus or stomach. While the incidence of gastric adenocarcinoma and oesophageal squamous cell carcinoma have declined in recent decades, oesophageal adenocarcinoma has increased more than any other cancer. Infection with Helicobacter pylori, dietary salt and smoking are the main risk factors for gastric and oesophageal cancer. Gastro-oesophageal reflux disease (GORD), Barrett s oesophagus and obesity are risk factors for oesophageal adenocarcinoma. Adenocarcinomas of the oesophago-gastric junction and cardia include two distinct types, one resembling gastric cancer caused by H.pylori infection, the other, associated with GORD, resembling Barrett s adenocarcinoma. Gender is also a major intrinsic factor, with upper gastrointestinal cancer much commoner in men. The current work examines this male predominance at the population level and with reference to Lauren histological type, showing that only intestinal-type but not diffuse type upper GI cancers occur more frequently in men.
One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in the GI tract is to control the gastric residence time (GRT) via gastroretentive drug delivery system which will provide us with new and important therapeutic options. Controlling the residence time of a drug delivery system in a particular region of GI tract can utilize several approaches which include floating drug delivery system, high density system and mucoadhesive system. Helicobacter pylori bacteria are the causative agents of gastric ulcers.Certain conventional dosage forms fail to eradicate the bacteria from the stomach so a novel drug delivery system is the need of the hour for proper elimination of these bacteria locally as well as systemically. The gastro retentive systems can be the remedy and the substitute for the conventional dosage forms, which will have more rationality with excellent efficacy towards the eradication of H.pylori infections. The focus of the research work in this book is to formulate,evaluate and optimize the newer gastro retentive dosage forms of various approaches.
The discovery of Helicobacter pylori as the cause of peptic ulcer has revolutionized anti-ulcer treatment. The current treatment includes a combination of antibiotics with proton pump inhibitors or H2 receptor antagonist1,2. Clarithromycin and omeprazole combination has become popular and best choice for treating peptic ulcer associated with H. pylori infection3. Gastro retentive dosage forms have the potential for increased residence in stomach along with site-specific drug delivery. Hydrodynamic drug delivery systems (HBS) are one such systems that has increased gastric residence providing an increased local action at the ulcer site4. Clarithromycin, effective in H.pylori infection treatment was chosen as model drug. Extended release and retention in upper gastro intestinal tract would be most advantageous, optimizing the combination therapy of peptic ulcer complicated with H.pylori. Omeprazole was formulated as fast dissolving enteric-coated pellets by using extrusion spheronisation technique. Enteric coating material used was Eudragit 30D-L-55.