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Beneficial effect of Curcumin on Helicobacter p...
51,30 € *
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Introduction: Peptic ulcer disease (PUD) is the erosion in lining of stomach or duodenum. Predominantly caused by Helicobacter pylori infection in about 50% of the world's population.which can colonize in the gastric antrum of all patients producing an extensive, noninvasive inflammatory reaction in the gastric mucosa.Methods: Fortey patients newly diagnosed endoscopically with peptic ulcer disease to be allocated into group 1 treated with standard H. pylori eradication triple therapy, and group 2 patients treated with curcumin (500 mg) capsules three times daily for 14 days as an adjuvant to standard triple therapy.Results: The result showed that the use of curcumin as adjuvant therapy produced highly significant improvement in healing efficacy which was significantly distinguished in duodenal ulcer patients compared to gastric ulcer groups 2 patients (p0.05), along with a highly significant reduction in pro-inflammatory IL-1beta level in group 2 patients (p0.01). Conclusion: This study revealed that addition of curcumin as adjuvant therapy produced improvement in ulcer healing efficacy, and controlled the inflammatory and oxidative stress process induced by H. pylori infection.

Anbieter: Dodax AT
Stand: 19.01.2020
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Beneficial effect of Curcumin on Helicobacter p...
49,90 € *
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Introduction: Peptic ulcer disease (PUD) is the erosion in lining of stomach or duodenum. Predominantly caused by Helicobacter pylori infection in about 50% of the world's population.which can colonize in the gastric antrum of all patients producing an extensive, noninvasive inflammatory reaction in the gastric mucosa.Methods: Fortey patients newly diagnosed endoscopically with peptic ulcer disease to be allocated into group 1 treated with standard H. pylori eradication triple therapy, and group 2 patients treated with curcumin (500 mg) capsules three times daily for 14 days as an adjuvant to standard triple therapy.Results: The result showed that the use of curcumin as adjuvant therapy produced highly significant improvement in healing efficacy which was significantly distinguished in duodenal ulcer patients compared to gastric ulcer groups 2 patients (p0.05), along with a highly significant reduction in pro-inflammatory IL-1beta level in group 2 patients (p0.01). Conclusion: This study revealed that addition of curcumin as adjuvant therapy produced improvement in ulcer healing efficacy, and controlled the inflammatory and oxidative stress process induced by H. pylori infection.

Anbieter: Dodax
Stand: 19.01.2020
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Effect of Antibiotics Loaded with Nanochitosan ...
41,10 € *
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Preface This book comes in a series directed the new world for the use of manufactured nano biological sources in the areas of diagnosis and treatment of diseases. A day nanochitosan is of biological assets safe delivery vehicles in the production of different nanostructure products used to carry therapeutic substances or in diagnosis of various diseases and pathogenic agents. The use of Nanochitosan to carry antibiotics to treat gastric ulcers caused by H. pylori bacteria is the new approach. The kinetics of exracellular metabolites are of important factors for monitoring the activities of infected bacteria under the effect of nanotherapy.

Anbieter: Dodax AT
Stand: 19.01.2020
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Effect of Antibiotics Loaded with Nanochitosan ...
39,90 € *
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Preface This book comes in a series directed the new world for the use of manufactured nano biological sources in the areas of diagnosis and treatment of diseases. A day nanochitosan is of biological assets safe delivery vehicles in the production of different nanostructure products used to carry therapeutic substances or in diagnosis of various diseases and pathogenic agents. The use of Nanochitosan to carry antibiotics to treat gastric ulcers caused by H. pylori bacteria is the new approach. The kinetics of exracellular metabolites are of important factors for monitoring the activities of infected bacteria under the effect of nanotherapy.

Anbieter: Dodax
Stand: 19.01.2020
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Oral Floating In Situ Gel System For Furazolidone
63,70 € *
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Helicobacter pylori (H. Pylori) infection is associated with many upper gastrointestinal diseases such as chronic gastritis, peptic ulcer and gastric carcinoma. Furazolidone is an effective drug in the treatment of GIT infections. Furazolidone has short half-life and need to administrate on frequent basis. This book discuss design, development and optimization of sustained release intra-gastric in situ floating gel system of Furazolidone for the potential use in treatment of gastric and duodenal ulcers associated with H. Pylori. Furazolidone gelling solution (FISG) was prepared using natural biodegradable polymers Xanthan gum, Gellan gum and Locust bean gum. The polymeric system was optimized by calcium carbonate and sodium citrate. Effect of beta CD was also evaluated. The optimized FISG was evaluated for gelling properties, floating lag time, rheological properties, drug content, FT-IR and DSC. All optimized solutions had shown pseudoplastic flow with good gel strength and gelled immediately at acidic pH 1.2. The dissolution study indicated sustained release of drug. The book will be useful for the researchers working in the areas of formulation development of pharmaceuticals.

Anbieter: Dodax AT
Stand: 19.01.2020
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Nucleotide synthesis and regulation in a human ...
81,30 € *
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Understanding the physiology of bacterial pathogens is essential to design more effective therapies. Thus the biochemical and molecular characteristics of aspartate carbamoyltransferase, the first step in pyrimidine biosynthesis, was investigated in the human pathogen Helicobacter pylori. Using enzymatic analysis procedures including NMR spectroscopy and radioactive tracer analysis, the regulatory properties of H. pylori ACTase were determined. The results indicated that the first step in this pathway of H. pylori was highly regulated. To determine whether ACTase plays an essential role in cell survival in H. pylori, an attempt was made to construct a mutant deficient in this enzyme activity. However, no mutants were isolated. These findings suggest ACTase is essential for survival of H. pylori. As ACTase appeared to be a potential therapeutic target, the effects of PALA, a potent inhibitor of this enzyme, was tested on cell viability. However, PALA had no effect on the viability of the cells. The results suggested H. pylori transformed the inhibitor into non-cytotoxic products, thus providing the bacterium with a mechanism of resistance that appears unique.

Anbieter: Dodax AT
Stand: 19.01.2020
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Oral Floating In Situ Gel System For Furazolidone
61,90 € *
ggf. zzgl. Versand

Helicobacter pylori (H. Pylori) infection is associated with many upper gastrointestinal diseases such as chronic gastritis, peptic ulcer and gastric carcinoma. Furazolidone is an effective drug in the treatment of GIT infections. Furazolidone has short half-life and need to administrate on frequent basis. This book discuss design, development and optimization of sustained release intra-gastric in situ floating gel system of Furazolidone for the potential use in treatment of gastric and duodenal ulcers associated with H. Pylori. Furazolidone gelling solution (FISG) was prepared using natural biodegradable polymers Xanthan gum, Gellan gum and Locust bean gum. The polymeric system was optimized by calcium carbonate and sodium citrate. Effect of beta CD was also evaluated. The optimized FISG was evaluated for gelling properties, floating lag time, rheological properties, drug content, FT-IR and DSC. All optimized solutions had shown pseudoplastic flow with good gel strength and gelled immediately at acidic pH 1.2. The dissolution study indicated sustained release of drug. The book will be useful for the researchers working in the areas of formulation development of pharmaceuticals.

Anbieter: Dodax
Stand: 19.01.2020
Zum Angebot
Nucleotide synthesis and regulation in a human ...
79,00 € *
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Understanding the physiology of bacterial pathogens is essential to design more effective therapies. Thus the biochemical and molecular characteristics of aspartate carbamoyltransferase, the first step in pyrimidine biosynthesis, was investigated in the human pathogen Helicobacter pylori. Using enzymatic analysis procedures including NMR spectroscopy and radioactive tracer analysis, the regulatory properties of H. pylori ACTase were determined. The results indicated that the first step in this pathway of H. pylori was highly regulated. To determine whether ACTase plays an essential role in cell survival in H. pylori, an attempt was made to construct a mutant deficient in this enzyme activity. However, no mutants were isolated. These findings suggest ACTase is essential for survival of H. pylori. As ACTase appeared to be a potential therapeutic target, the effects of PALA, a potent inhibitor of this enzyme, was tested on cell viability. However, PALA had no effect on the viability of the cells. The results suggested H. pylori transformed the inhibitor into non-cytotoxic products, thus providing the bacterium with a mechanism of resistance that appears unique.

Anbieter: Dodax
Stand: 19.01.2020
Zum Angebot
Helicobacter pylori cagA Gene Diversity
56,50 € *
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Helicobacter pylori cagPAI genes play an important role in pathogenesis, however little is known about their functions in isolates from Turkish patients. We aimed to evaluate the intactness and the effect of the cagPAI genes (cagT, cagM, cagE, cagA) and cagA EPIYA motifs on the AGS morphological changes and IL-8 induction. Isolates from gastritis, duodenal and gastric ulcer patients with intact and partially deleted cagPAI genes induced higher IL-8 secretion than those with complete deletions.Infection of AGS cells with isolates that possess intact cagPAI and EPIYA-ABC resulted in the formation of the hummingbird phenotype. The cagA positive isolates induced higher IL-8 secretion than cagA negative isolates. Isolates from DU patients with more than one EPIYA-C motif induced higher concentrations of IL-8 than those with EPIYA-ABC. In conclusion, the intactness of the cagPAI in our isolates from different patients was not conserved. An intact cagPAI was found to play an important role in the pathogenesis of DU but not GU or gastritis. The cagA gene, but not other cagPAI genes, was associated with the induction of IL-8 and the morphological changes of the AGS cells.

Anbieter: Dodax AT
Stand: 19.01.2020
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