Gastroduodenal Disease and Helicobacter pylori ab 138.99 € als Taschenbuch: Pathophysiology Diagnosis and Treatment. Softcover reprint of the original 1st ed. 1999. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Proteobacteria ab 20.99 € als Taschenbuch: Thiomargarita namibiensis Acetic acid bacteria Enterobacteriaceae Bdellovibrio Campylobacter Neisseria gonorrhoeae Helicobacter pylori Timeline of peptic ulcer disease and Helicobacter pylori Legionella. Aus dem Bereich: Bücher, Taschenbücher, Naturwissenschaft,
Peptic ulcer or Dyspepsia is one of the global`s diseases which causes mortality throughout the world, touching the lives of millions of peoples. For many years excess acid was believed to cause peptic ulcer. This misconception was suddenly illuminated due to the discovery of Helicobacter pylori bacteria which play a great role in the cause of peptic ulcer disease. To treat peptic ulcer natural products and modern synthetic drugs are in used but, still a complete cure has not been discovered and exploration of new antiulcer drugs has remain a field of active research. In this research a ground leaves of Tapinanthus dodoneifolius were macerated. The fractions obtained where subjected to phytochemicals screening, Antioxidant activity using DPPH and Antiulcer activity using an in vivo method on small animals. Causes, symptoms and treatment of peptic ulcer disease were discussed. The study has been a contribution to the assessment of possible antioxidant and antiulcer substances and should be useful to Biologist, Biochemists, Chemists, Health workers and other Medical practitioners.
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.
Identifying Helicobacter infection as the leading cause of peptic ulcer disease and gastric cancer has dramatically altered the treatment of these disease states. Over the last several decades, scientists have come to understand that the interplay between the bacteria, the host, and the environment all contribute to the clinical outcome of infection. In Helicobacter Species: Methods and Protocols, expert researchers in the field detail many of the methods and which are now commonly used to study Helicobacter infection. These include protocols and methods that have evolved over time, and standards across the field have been established which are essential for optimal outcomes and to allow comparison of data across different laboratories. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Helicobacter Species: Methods and Protocols seeks to aid scientists in further study of this crucially important research into Helicobacter research.
Gastric ulcers are erupted when there is an disproportion between the digestive juices generated by the stomach and the diverse factors that defend the mucosal lining of the stomach. Acute gastric problem reduces quickly but Chronic gastric problems lead to ulcers. Nine out of ten Peptic ulcer disease(PUD) or peptic ulcer or stomach ulcer (Gastric and duodenal ulcers) are sore on the inner lining of stomach or deodenum and caused by an infection from the bacterium H. pylori and they are liable to reappear if left untreated. An ulcer in the stomach is called as a gastric ulcer, an ulcer in the duodenum is known as a duodenal ulcer, and a peptic ulcer of the esophagus is an esophageal ulcer. Peptic ulcer disease is suspect in patients with epigastic distress and pain. Peptic ulcers are usually caused by either Helicobacter pylori (H. pylori) bacteria or non-steroidal anti-inflammatory drugs such as Aspirin, Ibuprofen or other NSAIDs.
Peptic ulcer disease (encompassing gastric ulcer and duodenal ulcer) disease affects a large portion of the world population. This occurs due to an imbalance between offensive and defensive factors. Helicobacter pylori infection is recognized as the leading cause of ulcer in the world, particularly in non developed countries, it comes under offensive factors and other agents such as alcohol and non steroidal anti-inflammatory drugs gain importance in developed countries comes under defensive factors. Nowadays the main line of approach in the treatment of peptic ulceration is the eradication of H. pylori infection. A large number of anti-ulcer drugs, including antibiotics, proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer disease, but clinical evaluations of these drugs have shown incidence of relapse, side effects, drug interactions and rebound hyper secretion following drug withdrawal which leads to high ulcer relapse rate. This has been the rationale for the development of new anti-ulcer drugs and thus search for novel molecules has been extended from plant sources that can offer better protection and have better safety profile.
An optimized Ethylcellulose microspheres of Clarithromycin were successfully prepared using emulsion/ solvent evaporation method and Con-A was successfully attached to the microspheres using carbodiimide method. Attachment of lectin to the Ethylcellulose microspheres significantly increased the mucoadhesiveness and also controls the release of Clarithromycin in simulated GI fluids. Conjugation aggregation assay suggesting that the lectin can be able to target in the treatment of Helicobacter pylori infection in peptic ulcer disease. Gamma scintigraphy study suggesting that Con-A lectin conjugated Ethylcellulose microspheres have gained considerable attention due to their ability to adhere to the mucus layer, as well as to release the drug in a controlled manner. It is concluded that designed targeted delivery system could possibly increases the bioavailability of Clarithromycin and treated the gastric ulcer in an effective manner.