Helicobacter species pylori represent one of the medically prominent and most common infections in the world. Contamination with this microbe has set as a causal factor in the development of gastritis, peptic ulcer, and gastric neoplasia. Consequently, prompt diagnosis is essential. Therefore, regarding all facts about the strong correlation between H. pylori and different upper gastrointestinal lesions, it is very crucial to specify the presence of this bacteria in gastric biopsy reports as it has an important role in the therapeutic implications too. Since, over years pathologists have sought different reliable methods for detecting H. pylori in biopsy specimens, including special stains, immunohistochemistry (IHC), polymerase chain reaction (PCR), and lately, in situ hybridization.
There are controversies regarding relationship between Helicobacter pylori (H. pylori) and upper gastro-intestinal bleeding (UGIB )in children. The goal of this study was to assess the relationship between H. pylori infection and UGIB in Northern Iranian children. One hundred children who had UGIB indicated for upper gastrointestinal endoscopy and 100 children without UGIB who were candidate for upper endoscopy because of chronic abdominal pain considered as their controls. After stabling vital sign, nasogastric tube inserted and washing was done then within 24 hours of admission, endoscopy conducted for all children in the case group (under general anesthesia). Upper endoscopy was done for all participants by a children gastroenterologist. A single pathologist reviewed all specimens. Mean age of cases was 6.2±3.2 years and mean age of controls was 7.1±2.9 years respectively. There was no relationship between H. pylori and UGIB. Erosion in fondus was significantly higher in cases (0.001) and erythema in antrum was significantly higher in controls (p0.001).
The presence of Helicobacter pylori in sewage water was confirmed, thus there is a reservoir for H. pylori outside of the human stomach. In aquatic environment, this bacterium transforms from the characteristic bacillary form to coccal or cocco-bacilli form, which is non culturable. However, Culturing this bacterium for the first time by the use of MDCS method took place. Here is a similarity between H. pylori found in sewage and those obtained from clinical biopsy and drinking water as indicated by RFLP technique raising the possibility for a fecal-oral route of transmission
Gastric ulcers are erupted when there is an disproportion between the digestive juices generated by the stomach and the diverse factors that defend the mucosal lining of the stomach. Acute gastric problem reduces quickly but Chronic gastric problems lead to ulcers. Nine out of ten Peptic ulcer disease(PUD) or peptic ulcer or stomach ulcer (Gastric and duodenal ulcers) are sore on the inner lining of stomach or deodenum and caused by an infection from the bacterium H. pylori and they are liable to reappear if left untreated. An ulcer in the stomach is called as a gastric ulcer, an ulcer in the duodenum is known as a duodenal ulcer, and a peptic ulcer of the esophagus is an esophageal ulcer. Peptic ulcer disease is suspect in patients with epigastic distress and pain. Peptic ulcers are usually caused by either Helicobacter pylori (H. pylori) bacteria or non-steroidal anti-inflammatory drugs such as Aspirin, Ibuprofen or other NSAIDs.
High Quality Content by WIKIPEDIA articles! A flagellum (pronounced /fl d l m/, plural: flagella) is a tail-like projection that protrudes from the cell body of certain prokaryotic and eukaryotic cells, and functions in locomotion. There are some notable differences between prokaryotic and eukaryotic flagella, such as protein composition, structure, and mechanism of propulsion. An example of a flagellated bacterium is the ulcer-causing Helicobacter pylori, which uses multiple flagella to propel itself through the mucus lining to reach the stomach epithelium. An example of a eukaryotic flagellated cell is the sperm cell, which uses its flagellum to propel itself through the female reproductive tract. Eukaryotic flagella are structurally identical to eukaryotic cilia, although distinctions are sometimes made according to function and/or length.
Recently the diabetes mellitus has been known as one of the main cause of upper gastrointestinal symptoms. Since high prevalence of Helicobacter Pylori in diabetic patients has been reported. The aim of this study was to evaluate the relationship between the level of gastric juice Nitric Oxide, Oxidative Stress and Hyperglycemic Control in diabetic H. Pylori infected patients. In patients with metabolically uncontrolled diabetes mellitus the prevalence of H. Pylori infection is high and the bacteria colonization occurs at the antrum of stomach. After eradication therapy of H. Pylori the control of the glyceamia will be useful. Increased levels of HbA1C in the case group in comparison with those in the uninfected subjects confirm the finding. On the other hand the treatment of the H. Pylori infection improves the level of NO° in the gastric juice and reduces cellular damage resulting from acute oxidative stress produced by reaction between superoxide radicals of H. Pylori and NO° of the gastric juice.
This book is about the study of association between Helicobacter Pylori (H. pylori) and Chronic Obstructive Pulmonary Disease (COPD). In past years, many studies have been carried out to understand the complex relationship between H. pylori infection and COPD. Few researches have been successful in showing the epidemiologic and serologic evidence for relationship between these two phenomenon. In our study, we aimed to investigate the seroprevalence of Helicobacter pylori in patients with COPD and to determine whether there is an association between H. pylori infection and COPD. The results from our study suggest that there is higher prevalence of H. pylori seropositivity in COPD patients than in non-COPD patients and that HP infection has a positive correlation with the severity of COPD showing the prevalence of HP infection increases with the severeness of COPD. But we were not able to find out the reason for H. pylori infection being related to COPD since our study was carried out in a very small scale and short period of time. To understand the complex relationship between H. pylori infection and COPD, we look forward for a better technical support and a bigger study group.
Hyper-chlorohydria has been long implicated in the etiology of duodenal ulcer(DU). Of late, H. pylori has been associated in the pathogenesis. while hyper-chlorohydria and Helicobacter infection can act throughout the gastroduodenum, it remains unexplained, why there should have predilection for certain well documented and specific sites for peptic ulceration. It has to be explained whether they produce any change in other parts of the stomach besides the ulcer site.Recent works like eradication of H. pylori, leading to healing of peptic ulcer diseases(PUDs) have given encouraging results and proved beyond doubt an association between H. pylori and PUD. Pain,a well known symptom of DU is often experienced throughout the stomach, often associated with generalized tenderness of the epigastrium suggesting possible generalized involvement of the gastric wall. In some cases of CDU, gross dilatation of stomach wall with generalized hypotonia is a common finding. In some others, hypertonic stomach with same pathology is not uncommon. It would therefore be interesting to study the structural changes in the stomach wall in CDU patients which i have tried to describe in this book.
BACKGROUND:Chronic bacterial infection may be a causative agent that explains part of the link between childhood poverty and adult coronary heart disease. Hence, search for new risk factors in the development of unstable angina especially the infections like helicobacter pylori . Most of the studies showed either inconsistent association between unstable angina and Helicobacter pylori infection . Hence, we are justified in conducting a study to know the association between unstable angina and Helicobacter pylori infection. METHODS:30 patients admitted in Kasturba medical hospitals admitted with the history of unstable angina were evaluated for helicobacter pylori infection by the serological test of IgG H.Pylori by ELISA method. 30 age and sex matched controls were studied and evaluated by the similar method. RESULTS:Out of 30 cases, 15 were positive for IgG H.Pylori (50%) and out of 30 controls 14 were positive for H.Pylori (46.66%). The P value was found to be 0.79. Hence, it was not statistically significant. CONCLUSION:Based on our small study we found that there is no association between Unstable angina and Helicobacter pylori infection.