Nucleotide synthesis and regulation in a human gut pathogen ab 78.99 € als Taschenbuch: Novel regulation of pyrimidine biosynthesis in the bacterial pathogen Helicobacter pylori. Aus dem Bereich: Bücher, Wissenschaft, Biologie,
The etiology of chronic spontaneous urticaria often remains un-established despite extensive investigative workup rendering cause specific management difficult. Foods, drugs, inhalants, systemic diseases, autoimmunity, and stress have been implicated frequently. Focal bacterial, viral and parasitic infections too have been involved in a significant number of cases and treating them empirically remains an unsubstantiated method in urticaria management. Helicobacter pylori infection has been also linked to chronic urticaria in 60-71% patients. Interestingly, H. pylori eradication treatment may lead to remission of urticaria in up to 80% patients including antihistamine unresponsive cases. The study notes a higher prevalence of asymptomatic H. pylori infection in a subset of chronic urticaria patients compared to controls. How it influences the chronicity, recurrences, severity or other manifestations of urticaria/angioedema, and its remission after eradication therapy remains conjectural in view of high endemicity of infection in developing countries in general.
This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori . Accordingly, it offers a valuable asset for scientists and clinicians alike.
This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens ( Salmonella , Shigella , Yersinia , Listeria and Helicobacter ), respiratory pathogens ( Mycobacterium , Legionella , Burkholderia and Streptococcus ) as well as skin and soft tissue pathogens ( Francisella and Staphylococcus ). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic.
This book provides a detailed review of the most recent pathogenetic, diagnostic and therapeutic approaches in connection with Helicobacter pylori, along with priority areas in research and trends in clinical practice to address this significant pathogen acknowledged as the causative agent in a wide range of diseases, including gastric adenocarcinoma, MALT lymphoma and immune thrombocytopenic purpura (ITP). Medical authorities worldwide now recommend a "test and treat" strategy for this bacterial infection. Eradication therapy approaches range from general mass eradication therapy to tailor-made therapy for antibiotic-resistant refractory infection. In regions with high prevalence of H. pylori infection, the infection itself would be considered a major parameter to predict the risk of gastric adenocarcinoma development. The main interest has shifted recently to the risk stratification strategy for gastric cancer development and to the wide-ranging application of its serological prevention program.This book will benefit all gastroenterologists, hematologists, dermatologists, primary care doctors, epidemiologists, physicians who related with community hygiene, as well as basic scientists, particularly microbiologists, bacteriologists, pathologists, molecular biologists, biochemists, immunologists and oncologists.
Bacterial infections cause substantial morbidity and mortality in cancer patients. These infections always remained enigmatic due to initial reluctance of cancer researchers in understanding their etiologic potential. Etiological association of bacteria with cancer gained credibility after discovery of carcinogenic potential of Helicobacter pylori. Moreover, other suspected associations including Salmonella typhi and gallbladder cancer, Streptococcus bovis and colon cancer and Chlamydia pneumoniae with ocular adnexal lymphoma etc. are looking for a legitimate appraisal to unravel their etiologic potential without prejudice. In contrary, bacteria also shows protective role for certain types of cancer. Certain agents derived from bacteria are successfully used for the management of cancer. The integrate association of bacteria and cancer association is evident in both positive and negative aspects. The role of bacteria in cancer etiology and treatment has been vigorously studied since last few years. Present book tries to provide current status of research undergoing in above direction, with the glimpses of future possibility for utilizing microbiological knowledge in the management of this deadly killer. This book will interest specialist dealing with cancer associated infectious complications, researchers working in the field of cancer biology, teachers and scientist in the field of microbiology, biotechnology, medicine and oncology. The unique coverage of bacteriology and cancer association in both positive and negative way can usher into to development of novel thrust area for microbiology students and experts.
This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori , which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike.
Helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world's population. H. pylori is also classified as class I carcinogen by the World Health Organization (WHO). There is a wide spectrum of clinical consequences by H. pylori, ranging from gastric cancer to ulceration of the gastrointestinal tract. The pathogenicity of the infection depends on the strain virulence, host susceptibility and environmental co-factors. During the process of H. pylori infection, the antigens secreted from the bacterium elicit strong humoral immune responses which may serve as prospective infection biomarkers. The infection has both direct and indirect impact on economic and overall well-being of patients, hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits and vaccines.
Gall stones are a major cause of morbidity throughout the world, it represents a prevalent and costly health problem .The old axiom, that a typical gall stone sufferer is a fat, fertile, female of fifty, is only partially true, as the disease has been found in women soon after their first delivery and also in underweight and thin people . Other factors like bacterial population include Helicobacter pylori could have a possible role in gall stone formation. This book analyzed the risk factors for gall stone in Basra including Helicobacter pylori infection .